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Serious Head-On Car Accident on MO 21 in Pilot Knob, MO, on October 25, 2026

Serious injuries reported after head-on crash in Pilot Knob

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Published:
October 26, 2026
|
Last Updated:
2 days ago

Pilot Knob, Iron County, MO

 (

Oct 25, 2026

) - 

A 35-year-old Ironton man was seriously injured in an October 25, 2026, crash on MO 21 in Pilot Knob, Missouri. His Chevrolet Suburban collided head-on with a GMC Sierra before leaving the road and overturning. He was airlifted to a St. Louis hospital, while the Sierra's 40-year-old driver was uninjured.
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A 35-year-old Ironton man driving a Chevrolet Suburban was airlifted to a St. Louis hospital with serious injuries after a crash on MO 21 in Pilot Knob, Missouri, on October 25, 2026.

The Missouri State Highway Patrol responded to the Iron County crash at about 2:40 p.m.

According to the patrol's crash report, the Suburban was heading north when it crossed the center of MO 21 and struck a southbound GMC Sierra head-on. The Suburban then left the roadway to the right and rolled over.

The Sierra's driver, a 40-year-old Caledonia woman, was not injured. The report listed her as wearing a seat belt and the Suburban's driver as not wearing one.

The Suburban was a total loss, while the Sierra sustained minor damage.

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Accident Victims:
Accident Victim
Name:
Age:
35
Injury:
Serious
Accident Victim
Name:
Age:
40
Injury:
No Injury
Accident Details:
Location:
Pilot Knob, Iron County, MO
Type:
Car Accident
Severity:
Serious
Collision:
Head On, Rollover, Multi-Vehicle
Issues:
Road Departure
Highway:
MO 21
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