Fatal Truck Accident on I-270 in South St. Louis County, Missouri, Reported November 05, 2026

Two men died following a crash involving three vehicles on northbound Interstate 270 near the Missouri Route 21 interchange in south St. Louis County, Missouri. The crash was reported November 5, 2026. The Missouri Department of Transportation reported it at about 3:55 a.m.

The Missouri State Highway Patrol said the sequence began with a collision between a trash truck and a pickup truck. Police stopped the two vehicles in the third lane of the northbound interstate following that initial crash.

A semitruck then approached the stopped vehicles. Its driver did not see them in time to stop, according to the patrol. The driver steered to the right in an attempt to avoid a collision, but the semitruck struck the pickup. That impact caused the pickup to hit the trash truck.

The tractor-trailer driver, a 58-year-old man, died. A 32-year-old man who was in the pickup suffered serious injuries and later died from those injuries.

The crash also involved a fire. All northbound lanes of I-270 were closed near the Route 21 interchange. Transportation officials said the closure was expected to last well into the morning hours. A confirmed reopening time was not provided in the available traffic information.